Jon Hamm spoke of the lingering sense of grief at losing both his parents as a young man.
The Mad Men star was an orphan by the age of 20, after first losing his mother to colon cancer when he was 10, followed by his father dying just as Hamm reached his second decade.
The 45-year-old Keeping Up With the Joneses star, who grew up in St. Louis, Missouri, was semi-adopted by family friends, who provided a support system as he grew up.
However, he revealed his regrets over never discussing the loss of his mother, who divorced his father when Hamm was two, with his other parent before he passed.
Hamm's father Daniel ran a family trucking business and, after his mother died, moved in with the actor.
"(My dad) was twice widowed," the actor told America's Elle magazine in a candid interview for its November (16) issue. "He was divorced from my mom when she died, but even so, there's a deep sense of tragedy in that. I never had the opportunity to, as an adult, sit down and talk to him about that. It's a real loss."
The 45-year-old actor, who shot to stardom after after starring as advertising executive Don Draper in AMC drama series Mad Men, moved to Los Angeles after college with just $150 (£122) in his pocket. And while he may have missed out on the support of his parents during his struggle to make it in Hollywood, he is appreciative of the support that he received from other quarters.
"Even today I get e-mails or cards from these women who, for lack of a better word, were my mom," Hamm shared. "We talk about what it means to be a family. Mostly it's about showing up. And being aware enough to check in and say, 'How are you doing?' I've been incredibly lucky to have these people in my life."
Hamm's latest film Keeping Up with the Joneses, which sees him play a spy who gets mixed up in the lives of a suburban couple, played by Zach Galifianakis and Isla Fisher, is released on 21 October (16).